diff --git a/Marlin/Conditionals_LCD.h b/Marlin/Conditionals_LCD.h
index 13dbf8a00..841838502 100644
--- a/Marlin/Conditionals_LCD.h
+++ b/Marlin/Conditionals_LCD.h
@@ -286,7 +286,7 @@
    *  HOTENDS      - Number of hotends, whether connected or separate
    *  E_STEPPERS   - Number of actual E stepper motors
    *  TOOL_E_INDEX - Index to use when getting/setting the tool state
-   *  
+   *
    */
   #if ENABLED(SINGLENOZZLE)             // One hotend, multi-extruder
     #define HOTENDS      1
@@ -316,6 +316,18 @@
     #define TOOL_E_INDEX current_block->active_extruder
   #endif
 
+  /**
+   * Distinct E Factors – Disable by commenting out DISTINCT_E_FACTORS
+   */
+  #if ENABLED(DISTINCT_E_FACTORS) && E_STEPPERS > 1
+    #define XYZE_N (XYZ + E_STEPPERS)
+    #define E_AXIS_N (E_AXIS + extruder)
+  #else
+    #undef DISTINCT_E_FACTORS
+    #define XYZE_N XYZE
+    #define E_AXIS_N E_AXIS
+  #endif
+
   /**
    * The BLTouch Probe emulates a servo probe
    * and uses "special" angles for its state.
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index e616fa3fd..5565afb3b 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 4000, 500 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 300, 300, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 3000, 3000, 100, 10000 }
 
diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index c02c02c74..8a9234e12 100755
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -1227,7 +1227,7 @@ inline bool code_value_bool() { return !code_has_value() || code_value_byte() >
   }
 
   inline float axis_unit_factor(int axis) {
-    return (axis == E_AXIS && volumetric_enabled ? volumetric_unit_factor : linear_unit_factor);
+    return (axis >= E_AXIS && volumetric_enabled ? volumetric_unit_factor : linear_unit_factor);
   }
 
   inline float code_value_linear_units() { return code_value_float() * linear_unit_factor; }
@@ -5772,22 +5772,38 @@ inline void gcode_M85() {
   if (code_seen('S')) max_inactive_time = code_value_millis_from_seconds();
 }
 
+/**
+ * Multi-stepper support for M92, M201, M203
+ */
+#if ENABLED(DISTINCT_E_FACTORS)
+  #define GET_TARGET_EXTRUDER(CMD) if (get_target_extruder_from_command(CMD)) return
+  #define TARGET_EXTRUDER target_extruder
+#else
+  #define GET_TARGET_EXTRUDER(CMD) NOOP
+  #define TARGET_EXTRUDER 0
+#endif
+
 /**
  * M92: Set axis steps-per-unit for one or more axes, X, Y, Z, and E.
  *      (Follows the same syntax as G92)
+ *
+ *      With multiple extruders use T to specify which one.
  */
 inline void gcode_M92() {
+
+  GET_TARGET_EXTRUDER(92);
+
   LOOP_XYZE(i) {
     if (code_seen(axis_codes[i])) {
       if (i == E_AXIS) {
-        float value = code_value_per_axis_unit(i);
+        float value = code_value_per_axis_unit(E_AXIS + TARGET_EXTRUDER);
         if (value < 20.0) {
-          float factor = planner.axis_steps_per_mm[i] / value; // increase e constants if M92 E14 is given for netfab.
+          float factor = planner.axis_steps_per_mm[E_AXIS + TARGET_EXTRUDER] / value; // increase e constants if M92 E14 is given for netfab.
           planner.max_jerk[E_AXIS] *= factor;
-          planner.max_feedrate_mm_s[E_AXIS] *= factor;
-          planner.max_acceleration_steps_per_s2[E_AXIS] *= factor;
+          planner.max_feedrate_mm_s[E_AXIS + TARGET_EXTRUDER] *= factor;
+          planner.max_acceleration_steps_per_s2[E_AXIS + TARGET_EXTRUDER] *= factor;
         }
-        planner.axis_steps_per_mm[E_AXIS] = value;
+        planner.axis_steps_per_mm[E_AXIS + TARGET_EXTRUDER] = value;
       }
       else {
         planner.axis_steps_per_mm[i] = code_value_per_axis_unit(i);
@@ -6038,11 +6054,17 @@ inline void gcode_M200() {
 
 /**
  * M201: Set max acceleration in units/s^2 for print moves (M201 X1000 Y1000)
+ *
+ *       With multiple extruders use T to specify which one.
  */
 inline void gcode_M201() {
+
+  GET_TARGET_EXTRUDER(201);
+
   LOOP_XYZE(i) {
     if (code_seen(axis_codes[i])) {
-      planner.max_acceleration_mm_per_s2[i] = code_value_axis_units(i);
+      const uint8_t a = i + (i == E_AXIS ? TARGET_EXTRUDER : 0);
+      planner.max_acceleration_mm_per_s2[a] = code_value_axis_units(a);
     }
   }
   // steps per sq second need to be updated to agree with the units per sq second (as they are what is used in the planner)
@@ -6060,11 +6082,18 @@ inline void gcode_M201() {
 
 /**
  * M203: Set maximum feedrate that your machine can sustain (M203 X200 Y200 Z300 E10000) in units/sec
+ *
+ *       With multiple extruders use T to specify which one.
  */
 inline void gcode_M203() {
+
+  GET_TARGET_EXTRUDER(203);
+
   LOOP_XYZE(i)
-    if (code_seen(axis_codes[i]))
-      planner.max_feedrate_mm_s[i] = code_value_axis_units(i);
+    if (code_seen(axis_codes[i])) {
+      const uint8_t a = i + (i == E_AXIS ? TARGET_EXTRUDER : 0);
+      planner.max_feedrate_mm_s[a] = code_value_axis_units(a);
+    }
 }
 
 /**
diff --git a/Marlin/configuration_store.cpp b/Marlin/configuration_store.cpp
index f1f898c4a..a3ae225b2 100644
--- a/Marlin/configuration_store.cpp
+++ b/Marlin/configuration_store.cpp
@@ -47,9 +47,9 @@
  *  100  Version (char x4)
  *  104  EEPROM Checksum (uint16_t)
  *
- *  106  M92 XYZE  planner.axis_steps_per_mm (float x4)
- *  122  M203 XYZE planner.max_feedrate_mm_s (float x4)
- *  138  M201 XYZE planner.max_acceleration_mm_per_s2 (uint32_t x4)
+ *  106  M92 XYZE  planner.axis_steps_per_mm (float x4 ... x7)
+ *  122  M203 XYZE planner.max_feedrate_mm_s (float x4 ... x7)
+ *  138  M201 XYZE planner.max_acceleration_mm_per_s2 (uint32_t x4 ... x7)
  *  154  M204 P    planner.acceleration (float)
  *  158  M204 R    planner.retract_acceleration (float)
  *  162  M204 T    planner.travel_acceleration (float)
@@ -571,10 +571,10 @@ void Config_Postprocess() {
 void Config_ResetDefault() {
   const float tmp1[] = DEFAULT_AXIS_STEPS_PER_UNIT, tmp2[] = DEFAULT_MAX_FEEDRATE;
   const long tmp3[] = DEFAULT_MAX_ACCELERATION;
-  LOOP_XYZE(i) {
-    planner.axis_steps_per_mm[i] = tmp1[i];
-    planner.max_feedrate_mm_s[i] = tmp2[i];
-    planner.max_acceleration_mm_per_s2[i] = tmp3[i];
+  LOOP_XYZE_N(i) {
+    planner.axis_steps_per_mm[i]          = tmp1[i < COUNT(tmp1) ? i : COUNT(tmp1) - 1];
+    planner.max_feedrate_mm_s[i]          = tmp2[i < COUNT(tmp2) ? i : COUNT(tmp2) - 1];
+    planner.max_acceleration_mm_per_s2[i] = tmp3[i < COUNT(tmp3) ? i : COUNT(tmp3) - 1];
   }
 
   planner.acceleration = DEFAULT_ACCELERATION;
@@ -719,8 +719,16 @@ void Config_ResetDefault() {
     SERIAL_ECHOPAIR("  M92 X", planner.axis_steps_per_mm[X_AXIS]);
     SERIAL_ECHOPAIR(" Y", planner.axis_steps_per_mm[Y_AXIS]);
     SERIAL_ECHOPAIR(" Z", planner.axis_steps_per_mm[Z_AXIS]);
-    SERIAL_ECHOPAIR(" E", planner.axis_steps_per_mm[E_AXIS]);
+    #if E_STEPPERS == 1
+      SERIAL_ECHOPAIR(" E", planner.axis_steps_per_mm[E_AXIS]);
+    #endif
     SERIAL_EOL;
+    #if ENABLED(DISTINCT_E_FACTORS)
+      for (uint8_t i = 0; i < E_STEPPERS; i++) {
+        SERIAL_ECHOPAIR("  M92 T", (int)i);
+        SERIAL_ECHOLNPAIR(" E", planner.axis_steps_per_mm[E_AXIS + i]);
+      }
+    #endif
 
     CONFIG_ECHO_START;
 
@@ -731,8 +739,16 @@ void Config_ResetDefault() {
     SERIAL_ECHOPAIR("  M203 X", planner.max_feedrate_mm_s[X_AXIS]);
     SERIAL_ECHOPAIR(" Y", planner.max_feedrate_mm_s[Y_AXIS]);
     SERIAL_ECHOPAIR(" Z", planner.max_feedrate_mm_s[Z_AXIS]);
-    SERIAL_ECHOPAIR(" E", planner.max_feedrate_mm_s[E_AXIS]);
+    #if E_STEPPERS == 1
+      SERIAL_ECHOPAIR(" E", planner.max_feedrate_mm_s[E_AXIS]);
+    #endif
     SERIAL_EOL;
+    #if ENABLED(DISTINCT_E_FACTORS)
+      for (uint8_t i = 0; i < E_STEPPERS; i++) {
+        SERIAL_ECHOPAIR("  M203 T", (int)i);
+        SERIAL_ECHOLNPAIR(" E", planner.max_feedrate_mm_s[E_AXIS + i]);
+      }
+    #endif
 
     CONFIG_ECHO_START;
     if (!forReplay) {
@@ -742,8 +758,17 @@ void Config_ResetDefault() {
     SERIAL_ECHOPAIR("  M201 X", planner.max_acceleration_mm_per_s2[X_AXIS]);
     SERIAL_ECHOPAIR(" Y", planner.max_acceleration_mm_per_s2[Y_AXIS]);
     SERIAL_ECHOPAIR(" Z", planner.max_acceleration_mm_per_s2[Z_AXIS]);
-    SERIAL_ECHOPAIR(" E", planner.max_acceleration_mm_per_s2[E_AXIS]);
+    #if E_STEPPERS == 1
+      SERIAL_ECHOPAIR(" E", planner.max_acceleration_mm_per_s2[E_AXIS]);
+    #endif
     SERIAL_EOL;
+    #if ENABLED(DISTINCT_E_FACTORS)
+      for (uint8_t i = 0; i < E_STEPPERS; i++) {
+        SERIAL_ECHOPAIR("  M201 T", (int)i);
+        SERIAL_ECHOLNPAIR(" E", planner.max_acceleration_mm_per_s2[E_AXIS + i]);
+      }
+    #endif
+
     CONFIG_ECHO_START;
     if (!forReplay) {
       SERIAL_ECHOLNPGM("Accelerations: P=printing, R=retract and T=travel");
diff --git a/Marlin/enum.h b/Marlin/enum.h
index d7042e2a8..23b1fd033 100644
--- a/Marlin/enum.h
+++ b/Marlin/enum.h
@@ -50,6 +50,7 @@ enum AxisEnum {
 
 #define LOOP_XYZ(VAR)  for (uint8_t VAR=X_AXIS; VAR<=Z_AXIS; VAR++)
 #define LOOP_XYZE(VAR) for (uint8_t VAR=X_AXIS; VAR<=E_AXIS; VAR++)
+#define LOOP_XYZE_N(VAR) for (uint8_t VAR=X_AXIS; VAR<XYZE_N; VAR++)
 
 typedef enum {
   LINEARUNIT_MM,
diff --git a/Marlin/example_configurations/Cartesio/Configuration.h b/Marlin/example_configurations/Cartesio/Configuration.h
index 815038529..64b7199e4 100644
--- a/Marlin/example_configurations/Cartesio/Configuration.h
+++ b/Marlin/example_configurations/Cartesio/Configuration.h
@@ -146,6 +146,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 3
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 71.128, 71.128, 640, 152 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_MAX_FEEDRATE          { 200, 200, 20, 20 }   // (mm/sec)
+#define DEFAULT_MAX_FEEDRATE          { 200, 200, 20, 20 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 1000, 1000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index cdd64c9a8..75f7a24a9 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -455,26 +458,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 76.190476, 76.190476, 1600, 164 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 5000, 5000, 100, 80000 }
 
diff --git a/Marlin/example_configurations/Felix/DUAL/Configuration.h b/Marlin/example_configurations/Felix/DUAL/Configuration.h
index 39ec8713f..ebfaff5c4 100644
--- a/Marlin/example_configurations/Felix/DUAL/Configuration.h
+++ b/Marlin/example_configurations/Felix/DUAL/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 2
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -455,26 +458,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 76.190476, 76.190476, 1600, 164 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 5000, 5000, 100, 80000 }
 
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index d8676d341..6d36ab057 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -148,6 +148,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -464,26 +467,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 4000, 100.47095761381482 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 200, 200, 3.3, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 1100, 1100, 100, 10000 }
 
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index de082c440..9b506b60f 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -466,26 +469,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 160, 160, 8000, 210.02 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 250, 250, 2, 200 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 1000, 1000, 20, 1000 }
 
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index 7b2ab52ac..60b70eb34 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -165,6 +165,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -502,25 +505,30 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   { 64.25, 64.25, 2560, 600}  // for K8200
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 64.25, 64.25, 2560, 600 }
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/K8400/Configuration.h b/Marlin/example_configurations/K8400/Configuration.h
index fb603c2fa..079b49e40 100644
--- a/Marlin/example_configurations/K8400/Configuration.h
+++ b/Marlin/example_configurations/K8400/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 134.74, 134.74, 4266.66, 148.7 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 160, 160, 10, 10000 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/K8400/Dual-head/Configuration.h b/Marlin/example_configurations/K8400/Dual-head/Configuration.h
index 203647b4c..139033702 100644
--- a/Marlin/example_configurations/K8400/Dual-head/Configuration.h
+++ b/Marlin/example_configurations/K8400/Dual-head/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 2
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 134.74, 134.74, 4266.66, 148.7 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 160, 160, 10, 10000 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 82feca575..5ffb1848a 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {78.7402*2,78.7402*2,5120.00,760*1*1.5}
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 78.7402*2, 78.7402*2, 5120.00, 760*1*1.5 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 300, 300, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 3000, 3000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index 6788e5a69..437179322 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -148,6 +148,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1  // Single extruder. Set to 2 for dual extruders
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -469,27 +472,33 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   { 44.3090, 22.1545, 1600, 53.5 }  // default steps per unit for RigidBot with standard hardware
-                                                                        // default steps for 16-tooth pulleys { 100.06, 50.06, 1600, 76 }, HPX2-MAX E=504, RigidBot E=53.5, Peter Stoneham's=76
+ // default steps per unit for RigidBot with standard hardware
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 44.3090, 22.1545, 1600, 53.5 }
+// default steps for 16-tooth pulleys { 100.06, 50.06, 1600, 76 } // HPX2-MAX E=504, RigidBot E=53.5, Peter Stoneham's=76
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 800, 800, 100, 10000 }
 
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index bd225c1fe..596add373 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -177,6 +177,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -487,26 +490,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {103.69,106.65,200/1.25,1000}  // default steps per unit for SCARA
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 103.69, 106.65, 200/1.25, 1000 }  // default steps per unit for SCARA
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 300, 300, 30, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 300, 300, 20, 1000 }
 
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index f256d619b..fb8ffc8d4 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -493,26 +496,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 100.5, 100.5, 400, 850 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 800, 800, 8, 50 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index 7434cbed6..b09f8a775 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -148,6 +148,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -464,26 +467,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {80,80,600.0*8/3,102.073}
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 600.0*8/3, 102.073 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 350, 350, 7.2, 80 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 1000, 1000, 10, 1000 }
 
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index 8f74f1fec..d6fe48735 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -472,26 +475,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 4000, 500 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 300, 300, 5, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 3000, 3000, 100, 10000 }
 
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration.h b/Marlin/example_configurations/delta/biv2.5/Configuration.h
index 524d609dc..a078b82a4 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 2
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -203,7 +206,7 @@
 
 /**
  * --NORMAL IS 4.7kohm PULLUP!-- 1kohm pullup can be used on hotend sensor, using correct resistor and table
- * 
+ *
  * Temperature sensors available:
  *
  *    -3 : thermocouple with MAX31855 (only for sensor 0)
@@ -228,13 +231,13 @@
  *    60 : 100k Maker's Tool Works Kapton Bed Thermistor beta=3950
  *    66 : 4.7M High Temperature thermistor from Dyze Design
  *    70 : the 100K thermistor found in the bq Hephestos 2
- * 
+ *
  *       1k ohm pullup tables - This is atypical, and requires changing out the 4.7k pullup for 1k.
  *                              (but gives greater accuracy and more stable PID)
  *    51 : 100k thermistor - EPCOS (1k pullup)
  *    52 : 200k thermistor - ATC Semitec 204GT-2 (1k pullup)
  *    55 : 100k thermistor - ATC Semitec 104GT-2 (Used in ParCan & J-Head) (1k pullup)
- * 
+ *
  *  1047 : Pt1000 with 4k7 pullup
  *  1010 : Pt1000 with 1k pullup (non standard)
  *   147 : Pt100 with 4k7 pullup
@@ -520,26 +523,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 72.9, 72.9, 72.9, 291 }  // default steps per unit for BI v2.5 (cable drive)
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 500, 150 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 9000, 10000 }
 
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index a1d3d0b33..583f18cdf 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -520,26 +523,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {80, 80, 80, 760*1.1}  // default steps per unit for Kossel (GT2, 20 tooth)
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 80, 760*1.1 }  // default steps per unit for Kossel (GT2, 20 tooth)
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 500, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 9000, 10000 }
 
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index aaac12af8..266c202a0 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -520,26 +523,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {80, 80, 80, 760*1.1}  // default steps per unit for Kossel (GT2, 20 tooth)
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { 80, 80, 80, 760*1.1 }  // default steps per unit for Kossel (GT2, 20 tooth)
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 500, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 9000, 10000 }
 
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index d1e9ec540..f223c8f8b 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -149,6 +149,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -514,26 +517,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {XYZ_STEPS, XYZ_STEPS, XYZ_STEPS, 184.8}
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { XYZ_STEPS, XYZ_STEPS, XYZ_STEPS, 184.8 }
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 200, 200, 200, 200 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 9000, 9000 }
 
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index 0fa5c0a7b..699740cdc 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -138,6 +138,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -526,26 +529,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
-#define DEFAULT_AXIS_STEPS_PER_UNIT   {XYZ_STEPS, XYZ_STEPS, XYZ_STEPS, 158}   // default steps per unit for PowerWasp
+#define DEFAULT_AXIS_STEPS_PER_UNIT   { XYZ_STEPS, XYZ_STEPS, XYZ_STEPS, 158 }   // default steps per unit for PowerWasp
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 200, 200, 200, 25 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 9000, 10000 }
 
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index 7199f2295..f56873302 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -475,26 +478,31 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 400, 400, 400, 163 }     // default steps per unit for ***** MakiBox A6 *****
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 60, 60, 20, 45 }
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 2000, 2000, 30, 10000 }
 
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index 2bd08d95a..efa64e762 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -145,6 +145,9 @@
 // :[1, 2, 3, 4]
 #define EXTRUDERS 1
 
+// Enable if your E steppers or extruder gear ratios are not identical
+//#define DISTINCT_E_FACTORS
+
 // For Cyclops or any "multi-extruder" that shares a single nozzle.
 //#define SINGLENOZZLE
 
@@ -462,30 +465,35 @@
  *
  * These settings can be reset by M502
  *
+ * You can set distinct factors for each E stepper, if needed.
+ * If fewer factors are given, the last will apply to the rest.
+ *
  * Note that if EEPROM is enabled, saved values will override these.
  */
 
 /**
  * Default Axis Steps Per Unit (steps/mm)
  * Override with M92
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_AXIS_STEPS_PER_UNIT   { 71.1, 71.1, 2560, 600 } // David TVRR
 
-//#define DEFAULT_AXIS_STEPS_PER_UNIT   {79.87, 79.87, 2566, 563,78} // Al's TVRR
+//#define DEFAULT_AXIS_STEPS_PER_UNIT   { 79.87, 79.87, 2566, 563.78 } // Al's TVRR
 //#define DEFAULT_AXIS_STEPS_PER_UNIT   { 81.26, 80.01, 2561, 599.14 } // Michel TVRR old
 //#define DEFAULT_AXIS_STEPS_PER_UNIT   { 71.1, 71.1, 2560, 739.65 } // Michel TVRR
 
 /**
  * Default Max Feed Rate (mm/s)
  * Override with M203
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_FEEDRATE          { 500, 500, 5, 45 } // David TVRR
 
 /**
  * Default Max Acceleration (change/s) change = mm/s
+ * (Maximum start speed for accelerated moves)
  * Override with M201
- *
- * Maximum start speed for accelerated moves: { X, Y, Z, E }
+ *                                      X, Y, Z, E0 [, E1[, E2[, E3]]]
  */
 #define DEFAULT_MAX_ACCELERATION      { 9000, 9000, 100, 10000 }
 
diff --git a/Marlin/planner.cpp b/Marlin/planner.cpp
index bd30c6a23..73bdb0cf0 100644
--- a/Marlin/planner.cpp
+++ b/Marlin/planner.cpp
@@ -81,12 +81,16 @@ block_t Planner::block_buffer[BLOCK_BUFFER_SIZE];
 volatile uint8_t Planner::block_buffer_head = 0,           // Index of the next block to be pushed
                  Planner::block_buffer_tail = 0;
 
-float Planner::max_feedrate_mm_s[NUM_AXIS], // Max speeds in mm per second
-      Planner::axis_steps_per_mm[NUM_AXIS],
-      Planner::steps_to_mm[NUM_AXIS];
+float Planner::max_feedrate_mm_s[XYZE_N], // Max speeds in mm per second
+      Planner::axis_steps_per_mm[XYZE_N],
+      Planner::steps_to_mm[XYZE_N];
 
-uint32_t Planner::max_acceleration_steps_per_s2[NUM_AXIS],
-         Planner::max_acceleration_mm_per_s2[NUM_AXIS]; // Use M201 to override by software
+#if ENABLED(DISTINCT_E_FACTORS)
+  uint8_t Planner::last_extruder = 0;     // Respond to extruder change
+#endif
+
+uint32_t Planner::max_acceleration_steps_per_s2[XYZE_N],
+         Planner::max_acceleration_mm_per_s2[XYZE_N]; // Use M201 to override by software
 
 millis_t Planner::min_segment_time;
 float Planner::min_feedrate_mm_s,
@@ -650,9 +654,17 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
     lround(a * axis_steps_per_mm[X_AXIS]),
     lround(b * axis_steps_per_mm[Y_AXIS]),
     lround(c * axis_steps_per_mm[Z_AXIS]),
-    lround(e * axis_steps_per_mm[E_AXIS])
+    lround(e * axis_steps_per_mm[E_AXIS_N])
   };
-  
+
+  // When changing extruders recalculate steps corresponding to the E position
+  #if ENABLED(DISTINCT_E_FACTORS)
+    if (last_extruder != extruder && axis_steps_per_mm[E_AXIS_N] != axis_steps_per_mm[E_AXIS + last_extruder]) {
+      position[E_AXIS] = lround(position[E_AXIS] * axis_steps_per_mm[E_AXIS_N] * steps_to_mm[E_AXIS + last_extruder]);
+      last_extruder = extruder;
+    }
+  #endif
+
   #if ENABLED(LIN_ADVANCE)
     float target_float[XYZE] = {a, b, c, e};
     float de_float = target_float[E_AXIS] - position_float[E_AXIS];
@@ -702,7 +714,7 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
         SERIAL_ECHOLNPGM(MSG_ERR_COLD_EXTRUDE_STOP);
       }
       #if ENABLED(PREVENT_LENGTHY_EXTRUDE)
-        if (labs(de) > (int32_t)axis_steps_per_mm[E_AXIS] * (EXTRUDE_MAXLENGTH)) { // It's not important to get max. extrusion length in a precision < 1mm, so save some cycles and cast to int
+        if (labs(de) > (int32_t)axis_steps_per_mm[E_AXIS_N] * (EXTRUDE_MAXLENGTH)) { // It's not important to get max. extrusion length in a precision < 1mm, so save some cycles and cast to int
           position[E_AXIS] = target[E_AXIS]; // Behave as if the move really took place, but ignore E part
           de = 0; // no difference
           SERIAL_ECHO_START;
@@ -941,7 +953,7 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
     delta_mm[Y_AXIS] = db * steps_to_mm[Y_AXIS];
     delta_mm[Z_AXIS] = dc * steps_to_mm[Z_AXIS];
   #endif
-  delta_mm[E_AXIS] = esteps_float * steps_to_mm[E_AXIS];
+  delta_mm[E_AXIS] = esteps_float * steps_to_mm[E_AXIS_N];
 
   if (block->steps[X_AXIS] < MIN_STEPS_PER_SEGMENT && block->steps[Y_AXIS] < MIN_STEPS_PER_SEGMENT && block->steps[Z_AXIS] < MIN_STEPS_PER_SEGMENT) {
     block->millimeters = fabs(delta_mm[E_AXIS]);
@@ -1091,16 +1103,16 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
     accel = ceil(retract_acceleration * steps_per_mm);
   }
   else {
-    #define LIMIT_ACCEL_LONG(AXIS) do{ \
-      if (block->steps[AXIS] && max_acceleration_steps_per_s2[AXIS] < accel) { \
-        const uint32_t comp = max_acceleration_steps_per_s2[AXIS] * block->step_event_count; \
+    #define LIMIT_ACCEL_LONG(AXIS,INDX) do{ \
+      if (block->steps[AXIS] && max_acceleration_steps_per_s2[AXIS+INDX] < accel) { \
+        const uint32_t comp = max_acceleration_steps_per_s2[AXIS+INDX] * block->step_event_count; \
         if (accel * block->steps[AXIS] > comp) accel = comp / block->steps[AXIS]; \
       } \
     }while(0)
 	
-    #define LIMIT_ACCEL_FLOAT(AXIS) do{ \
-      if (block->steps[AXIS] && max_acceleration_steps_per_s2[AXIS] < accel) { \
-        const float comp = (float)max_acceleration_steps_per_s2[AXIS] * (float)block->step_event_count; \
+    #define LIMIT_ACCEL_FLOAT(AXIS,INDX) do{ \
+      if (block->steps[AXIS] && max_acceleration_steps_per_s2[AXIS+INDX] < accel) { \
+        const float comp = (float)max_acceleration_steps_per_s2[AXIS+INDX] * (float)block->step_event_count; \
         if ((float)accel * (float)block->steps[AXIS] > comp) accel = comp / (float)block->steps[AXIS]; \
       } \
     }while(0)
@@ -1109,16 +1121,17 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
     accel = ceil((esteps ? acceleration : travel_acceleration) * steps_per_mm);
 
     // Limit acceleration per axis
-    if (block->step_event_count <= cutoff_long){
-      LIMIT_ACCEL_LONG(X_AXIS);
-      LIMIT_ACCEL_LONG(Y_AXIS);
-      LIMIT_ACCEL_LONG(Z_AXIS);
-      LIMIT_ACCEL_LONG(E_AXIS);
-    } else {
-      LIMIT_ACCEL_FLOAT(X_AXIS);
-      LIMIT_ACCEL_FLOAT(Y_AXIS);
-      LIMIT_ACCEL_FLOAT(Z_AXIS);
-      LIMIT_ACCEL_FLOAT(E_AXIS);
+    if (block->step_event_count <= cutoff_long) {
+      LIMIT_ACCEL_LONG(X_AXIS,0);
+      LIMIT_ACCEL_LONG(Y_AXIS,0);
+      LIMIT_ACCEL_LONG(Z_AXIS,0);
+      LIMIT_ACCEL_LONG(E_AXIS,extruder);
+    }
+    else {
+      LIMIT_ACCEL_FLOAT(X_AXIS,0);
+      LIMIT_ACCEL_FLOAT(Y_AXIS,0);
+      LIMIT_ACCEL_FLOAT(Z_AXIS,0);
+      LIMIT_ACCEL_FLOAT(E_AXIS,extruder);
     }
   }
   block->acceleration_steps_per_s2 = accel;
@@ -1302,7 +1315,7 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
     }
     else {
       block->use_advance_lead = true;
-      block->abs_adv_steps_multiplier8 = lround(extruder_advance_k * (de_float / mm_D_float) * block->nominal_speed / (float)block->nominal_rate * axis_steps_per_mm[E_AXIS] * 256.0);
+      block->abs_adv_steps_multiplier8 = lround(extruder_advance_k * (de_float / mm_D_float) * block->nominal_speed / (float)block->nominal_rate * axis_steps_per_mm[E_AXIS_N] * 256.0);
     }
 
   #elif ENABLED(ADVANCE)
@@ -1350,13 +1363,18 @@ void Planner::_buffer_line(const float &a, const float &b, const float &c, const
  */
 
 void Planner::_set_position_mm(const float &a, const float &b, const float &c, const float &e) {
+  #if ENABLED(DISTINCT_E_FACTORS)
+    #define _EINDEX (E_AXIS + active_extruder)
+    last_extruder = active_extruder;
+  #else
+    #define _EINDEX E_AXIS
+  #endif
   long na = position[X_AXIS] = lround(a * axis_steps_per_mm[X_AXIS]),
        nb = position[Y_AXIS] = lround(b * axis_steps_per_mm[Y_AXIS]),
        nc = position[Z_AXIS] = lround(c * axis_steps_per_mm[Z_AXIS]),
-       ne = position[E_AXIS] = lround(e * axis_steps_per_mm[E_AXIS]);
+       ne = position[E_AXIS] = lround(e * axis_steps_per_mm[_EINDEX]);
   stepper.set_position(na, nb, nc, ne);
   previous_nominal_speed = 0.0; // Resets planner junction speeds. Assumes start from rest.
-
   ZERO(previous_speed);
 }
 
@@ -1386,24 +1404,35 @@ void Planner::sync_from_steppers() {
  * Setters for planner position (also setting stepper position).
  */
 void Planner::set_position_mm(const AxisEnum axis, const float& v) {
-  position[axis] = lround(v * axis_steps_per_mm[axis]);
+  #if ENABLED(DISTINCT_E_FACTORS)
+    const uint8_t axis_index = axis + (axis == E_AXIS ? active_extruder : 0);
+    last_extruder = active_extruder;
+  #else
+    const uint8_t axis_index = axis;
+  #endif
+  position[axis] = lround(v * axis_steps_per_mm[axis_index]);
   stepper.set_position(axis, v);
   previous_speed[axis] = 0.0;
 }
 
 // Recalculate the steps/s^2 acceleration rates, based on the mm/s^2
 void Planner::reset_acceleration_rates() {
+  #if ENABLED(DISTINCT_E_FACTORS)
+    #define HIGHEST_CONDITION (i < E_AXIS || i == E_AXIS + active_extruder)
+  #else
+    #define HIGHEST_CONDITION true
+  #endif
   uint32_t highest_rate = 1;
-  LOOP_XYZE(i) {
+  LOOP_XYZE_N(i) {
     max_acceleration_steps_per_s2[i] = max_acceleration_mm_per_s2[i] * axis_steps_per_mm[i];
-    NOLESS(highest_rate, max_acceleration_steps_per_s2[i]);
+    if (HIGHEST_CONDITION) NOLESS(highest_rate, max_acceleration_steps_per_s2[i]);
   }
   cutoff_long = 4294967295UL / highest_rate;
 }
 
 // Recalculate position, steps_to_mm if axis_steps_per_mm changes!
 void Planner::refresh_positioning() {
-  LOOP_XYZE(i) steps_to_mm[i] = 1.0 / axis_steps_per_mm[i];
+  LOOP_XYZE_N(i) steps_to_mm[i] = 1.0 / axis_steps_per_mm[i];
   set_position_mm_kinematic(current_position);
   reset_acceleration_rates();
 }
diff --git a/Marlin/planner.h b/Marlin/planner.h
index 64153207c..9ba2e69f3 100644
--- a/Marlin/planner.h
+++ b/Marlin/planner.h
@@ -143,11 +143,15 @@ class Planner {
     static volatile uint8_t block_buffer_head,  // Index of the next block to be pushed
                             block_buffer_tail;
 
-    static float max_feedrate_mm_s[NUM_AXIS]; // Max speeds in mm per second
-    static float axis_steps_per_mm[NUM_AXIS];
-    static float steps_to_mm[NUM_AXIS];
-    static unsigned long max_acceleration_steps_per_s2[NUM_AXIS];
-    static unsigned long max_acceleration_mm_per_s2[NUM_AXIS]; // Use M201 to override by software
+    #if ENABLED(DISTINCT_E_FACTORS)
+      static uint8_t last_extruder;             // Respond to extruder change
+    #endif
+
+    static float max_feedrate_mm_s[XYZE_N],     // Max speeds in mm per second
+                 axis_steps_per_mm[XYZE_N],
+                 steps_to_mm[XYZE_N];
+    static unsigned long max_acceleration_steps_per_s2[XYZE_N],
+                         max_acceleration_mm_per_s2[XYZE_N]; // Use M201 to override by software
 
     static millis_t min_segment_time;
     static float min_feedrate_mm_s,
@@ -343,7 +347,13 @@ class Planner {
     static void set_position_mm_kinematic(const float position[NUM_AXIS]);
     static void set_position_mm(const AxisEnum axis, const float &v);
     static FORCE_INLINE void set_z_position_mm(const float &z) { set_position_mm(Z_AXIS, z); }
-    static FORCE_INLINE void set_e_position_mm(const float &e) { set_position_mm(E_AXIS, e); }
+    static FORCE_INLINE void set_e_position_mm(const float &e) {
+      set_position_mm(E_AXIS
+        #if ENABLED(DISTINCT_E_FACTORS)
+          + active_extruder
+        #endif
+      , e);
+    }
 
     /**
      * Sync from the stepper positions. (e.g., after an interrupted move)