diff --git a/Marlin/src/gcode/calibrate/G28.cpp b/Marlin/src/gcode/calibrate/G28.cpp
index c512edde0..ffd81c1ea 100644
--- a/Marlin/src/gcode/calibrate/G28.cpp
+++ b/Marlin/src/gcode/calibrate/G28.cpp
@@ -229,7 +229,7 @@ void GcodeSuite::G28(const bool always_home_all) {
     tool_change(0, 0, true);
   #endif
 
-  #if ENABLED(DUAL_X_CARRIAGE) || ENABLED(DUAL_NOZZLE_DUPLICATION_MODE)
+  #if ENABLED(DUAL_X_CARRIAGE)
     extruder_duplication_enabled = false;
   #endif