diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 2538128d3..e66f9c9f7 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index 4718b64e1..54615fd2e 100755
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -7328,8 +7328,8 @@ inline void gcode_M907() {
   uint8_t case_light_brightness = 255;
 
   void update_case_light() {
-    digitalWrite(CASE_LIGHT_PIN, case_light_on ? HIGH : LOW);
-    analogWrite(CASE_LIGHT_PIN, case_light_on ? case_light_brightness : 0);
+    digitalWrite(CASE_LIGHT_PIN, case_light_on != INVERT_CASE_LIGHT ? HIGH : LOW);
+    analogWrite(CASE_LIGHT_PIN, case_light_on != INVERT_CASE_LIGHT ? case_light_brightness : 0);
   }
 
   /**
diff --git a/Marlin/example_configurations/Cartesio/Configuration_adv.h b/Marlin/example_configurations/Cartesio/Configuration_adv.h
index b5b3546b8..680f49f58 100644
--- a/Marlin/example_configurations/Cartesio/Configuration_adv.h
+++ b/Marlin/example_configurations/Cartesio/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/Felix/Configuration_adv.h b/Marlin/example_configurations/Felix/Configuration_adv.h
index 50ef6f223..2f848454f 100644
--- a/Marlin/example_configurations/Felix/Configuration_adv.h
+++ b/Marlin/example_configurations/Felix/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/Hephestos/Configuration_adv.h b/Marlin/example_configurations/Hephestos/Configuration_adv.h
index 7ba3a61b9..5294766e6 100644
--- a/Marlin/example_configurations/Hephestos/Configuration_adv.h
+++ b/Marlin/example_configurations/Hephestos/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration_adv.h b/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
index fa22b59a8..d48952e1a 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/K8200/Configuration_adv.h b/Marlin/example_configurations/K8200/Configuration_adv.h
index 679cb6d07..b6acbff10 100644
--- a/Marlin/example_configurations/K8200/Configuration_adv.h
+++ b/Marlin/example_configurations/K8200/Configuration_adv.h
@@ -239,8 +239,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/K8400/Configuration_adv.h b/Marlin/example_configurations/K8400/Configuration_adv.h
index 4cf838e85..0df0c0d7d 100644
--- a/Marlin/example_configurations/K8400/Configuration_adv.h
+++ b/Marlin/example_configurations/K8400/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/RigidBot/Configuration_adv.h b/Marlin/example_configurations/RigidBot/Configuration_adv.h
index 18f96aabc..45671c143 100644
--- a/Marlin/example_configurations/RigidBot/Configuration_adv.h
+++ b/Marlin/example_configurations/RigidBot/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/SCARA/Configuration_adv.h b/Marlin/example_configurations/SCARA/Configuration_adv.h
index 4b9ecba4d..5f4e0e2cf 100644
--- a/Marlin/example_configurations/SCARA/Configuration_adv.h
+++ b/Marlin/example_configurations/SCARA/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/TAZ4/Configuration_adv.h b/Marlin/example_configurations/TAZ4/Configuration_adv.h
index 706ab81a5..7e6061864 100644
--- a/Marlin/example_configurations/TAZ4/Configuration_adv.h
+++ b/Marlin/example_configurations/TAZ4/Configuration_adv.h
@@ -234,8 +234,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/WITBOX/Configuration_adv.h b/Marlin/example_configurations/WITBOX/Configuration_adv.h
index 7ba3a61b9..5294766e6 100644
--- a/Marlin/example_configurations/WITBOX/Configuration_adv.h
+++ b/Marlin/example_configurations/WITBOX/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration_adv.h b/Marlin/example_configurations/delta/biv2.5/Configuration_adv.h
index b3468cba5..cabcff9cf 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/delta/generic/Configuration_adv.h b/Marlin/example_configurations/delta/generic/Configuration_adv.h
index 7587b1c23..591e89832 100644
--- a/Marlin/example_configurations/delta/generic/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/generic/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
index 7587b1c23..591e89832 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
index b1cdfe840..0a3becc21 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
@@ -231,8 +231,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
index fa838047c..318fe6ecc 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/makibox/Configuration_adv.h b/Marlin/example_configurations/makibox/Configuration_adv.h
index 3c65ea02e..749d842bd 100644
--- a/Marlin/example_configurations/makibox/Configuration_adv.h
+++ b/Marlin/example_configurations/makibox/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h b/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
index 9d5cd456a..0097c6db2 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
@@ -226,8 +226,11 @@
 
 // Define a pin to turn case light on/off
 //#define CASE_LIGHT_PIN 4
-//#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
-//#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#if PIN_EXISTS(CASE_LIGHT)
+  #define INVERT_CASE_LIGHT false   // Set to true if HIGH is the OFF state (active low)
+  //#define CASE_LIGHT_DEFAULT_ON   // Uncomment to set default state to on
+  //#define MENU_ITEM_CASE_LIGHT    // Uncomment to have a Case Light On / Off entry in main menu
+#endif
 
 //===========================================================================
 //============================ Mechanical Settings ==========================
diff --git a/Marlin/ultralcd.cpp b/Marlin/ultralcd.cpp
index dc7974145..a7104d4c1 100755
--- a/Marlin/ultralcd.cpp
+++ b/Marlin/ultralcd.cpp
@@ -581,7 +581,7 @@ void kill_screen(const char* lcd_msg) {
 
   #endif //SDSUPPORT
 
-  #if HAS_CASE_LIGHT && ENABLED(MENU_ITEM_CASE_LIGHT)
+  #if ENABLED(MENU_ITEM_CASE_LIGHT)
 
     extern bool case_light_on;
     extern void update_case_light();
@@ -607,7 +607,7 @@ void kill_screen(const char* lcd_msg) {
     //
     // Switch case light on/off
     //
-    #if HAS_CASE_LIGHT && ENABLED(MENU_ITEM_CASE_LIGHT)
+    #if ENABLED(MENU_ITEM_CASE_LIGHT)
       if (case_light_on)
         MENU_ITEM(function, MSG_LIGHTS_OFF, toggle_case_light);
       else