diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 15a8d6c36..aaefdfe2d 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -1730,4 +1730,8 @@ static_assert(COUNT(sanity_arr_3) <= XYZE_N, "DEFAULT_MAX_ACCELERATION has too m
   #error "POWER_LOSS_RECOVERY currently requires an LCD Controller."
 #endif
 
+#if ENABLED(FAST_PWM_FAN) && !(defined(ARDUINO) && !defined(ARDUINO_ARCH_SAM))
+  #error "FAST_PWM_FAN only supported by 8 bit CPUs."
+#endif
+
 #endif // _SANITYCHECK_H_
diff --git a/Marlin/src/module/temperature.cpp b/Marlin/src/module/temperature.cpp
index a32ed9129..1abcfb0dc 100644
--- a/Marlin/src/module/temperature.cpp
+++ b/Marlin/src/module/temperature.cpp
@@ -1385,7 +1385,7 @@ void Temperature::init() {
 #if ENABLED(FAST_PWM_FAN)
 
   void Temperature::setPwmFrequency(const pin_t pin, int val) {
-    #ifdef ARDUINO
+    #if defined(ARDUINO) && !defined(ARDUINO_ARCH_SAM)
       val &= 0x07;
       switch (digitalPinToTimer(pin)) {
         #ifdef TCCR0A