diff --git a/Marlin/src/HAL/HAL_AVR/SanityCheck.h b/Marlin/src/HAL/HAL_AVR/SanityCheck.h
index 4485b8f39..f87044971 100644
--- a/Marlin/src/HAL/HAL_AVR/SanityCheck.h
+++ b/Marlin/src/HAL/HAL_AVR/SanityCheck.h
@@ -97,20 +97,8 @@
 #endif // SPINDLE_LASER_ENABLE
 
 /**
- * TMC2208 software UART and ENDSTOP_INTERRUPTS both use pin change interrupts (PCI)
+ * The Trinamic library includes SoftwareSerial.h, leading to a compile error.
  */
-#if HAS_DRIVER(TMC2208) && ENABLED(ENDSTOP_INTERRUPTS_FEATURE) && !( \
-       defined(X_HARDWARE_SERIAL ) \
-    || defined(X2_HARDWARE_SERIAL) \
-    || defined(Y_HARDWARE_SERIAL ) \
-    || defined(Y2_HARDWARE_SERIAL) \
-    || defined(Z_HARDWARE_SERIAL ) \
-    || defined(Z2_HARDWARE_SERIAL) \
-    || defined(Z3_HARDWARE_SERIAL) \
-    || defined(E0_HARDWARE_SERIAL) \
-    || defined(E1_HARDWARE_SERIAL) \
-    || defined(E2_HARDWARE_SERIAL) \
-    || defined(E3_HARDWARE_SERIAL) \
-    || defined(E4_HARDWARE_SERIAL) )
-  #error "Select hardware UART for TMC2208 to use both TMC2208 and ENDSTOP_INTERRUPTS_FEATURE."
+#if HAS_TRINAMIC && ENABLED(ENDSTOP_INTERRUPTS_FEATURE)
+  #error "TMCStepper includes SoftwareSerial.h which is incompatible with ENDSTOP_INTERRUPTS_FEATURE. Disable ENDSTOP_INTERRUPTS_FEATURE to continue."
 #endif